The statistical analyses revealed no differences between the patients treated with devices (CPAP or MRD, n = 23) and those without device (n = 10), for changes in the following seven parameters: percentage weight reduction, kilos, BMI, AHI, ODI, arousal index and ESS (MWU p > 0.05). The same seven parameters were evaluated for gender differences. The men (n = 24) and women (n = 9) showed no significant differences in percentage weight GDC-0980 or BMI reduction. However, the data showed that the women lost less weight in kilograms compared to the men, which was the only observed gender difference.
The Spearman rank correlation test showed a significant positive correlation between reduction in BMI and AHI, r = 0.47 (p < 0.05), see Fig. 4, but not between AHI and ESS or arousal index. Further there was a compound leaf significant negative correlation between changes in ESS-score and percentage deep sleep, r = −0.45 (p < 0.05), Fig. 5. In baseline data there was a significant correlation between the percentage body fat and baseline AHI, r = 0.41 (p < 0.05). In addition, there was a significant negative correlation between age and baseline sleep efficiency, r = −0.45, as well as between age and baseline total sleep time, r = −0.45 (both p < 0.05). There were no further significant correlations between metabolic and sleep apnoea parameters.
The Spearman rank correlation test showed a significant positive correlation between reduction in BMI and AHI, r = 0.47 (p < 0.05), see Fig. 4, but not between AHI and ESS or arousal index. Further there was a compound leaf significant negative correlation between changes in ESS-score and percentage deep sleep, r = −0.45 (p < 0.05), Fig. 5. In baseline data there was a significant correlation between the percentage body fat and baseline AHI, r = 0.41 (p < 0.05). In addition, there was a significant negative correlation between age and baseline sleep efficiency, r = −0.45, as well as between age and baseline total sleep time, r = −0.45 (both p < 0.05). There were no further significant correlations between metabolic and sleep apnoea parameters.