Multivariate Cox regression analysis for all-cause mortality and cardiac mortality in hemodialysis patients.Models GZD824 patient survivalAll-cause mortalityModels of patient survivalCardiac mortalityHR (95% CI)pHR (95% CI)pModel 1Model 1 TN-C1 (1–1)0.000 TN-C1 (1–1)0.000Model 2Model 2 Age1.04 (1.02–1.06)0.000 Age1.04 (1.01–1.06)0.001 TN-C1.00 (1.00–1.00)0.000 TN-C1.00 (1.00–1.00)0.000Model 3Model 3 Age1.04 (1.01–1.06)0.000 Age1.03 (1.01–1.06)0.003 TN-C1.00 (1.00–1.00)0.000 TN-C1.00 (1.00–1.00)0.000 Systolic blood pressure1.01 (1.00–1.03)0.01 Systolic blood pressure1.01 (1.00–1.03)0.026Model 4 Age1.03 (1.01–1.05)0.004 TN-C1.00 (1.00–1.00)0.000 Systolic blood pressure1.02 (1.00–1.03)0.003 Albumin0.33 (0.15–0.70)0.004Full-size tableTable optionsView in workspaceDownload as CSV
Since the distribution of TN-C levels was curved to the right, we defined the median concentrations of TN-C (7765 ng/mL) as cut-off values, and patients were divided into two groups based on TN-C cut-off point. In the high TN-C group (TN-C > 7765 ng/mL), glucose level (p < 0.05), platelet counts (p < 0.05), bicarbonate level (p < 0.05), CVC ratio (p < 0.001), all-cause mortality (p < 0.001) and cardiac mortality (p < 0.001) were all higher than those in the low TN-C group, while blood flow rate (p < 0.05) was lower (Table 4). Kaplan–Meier survival curve revealed higher all-cause and cardiac mortality rates in the high TN-C group (Fig. 2a and b) (Log rank p = 0.000 and p = 0.001, respectively).
Since the distribution of TN-C levels was curved to the right, we defined the median concentrations of TN-C (7765 ng/mL) as cut-off values, and patients were divided into two groups based on TN-C cut-off point. In the high TN-C group (TN-C > 7765 ng/mL), glucose level (p < 0.05), platelet counts (p < 0.05), bicarbonate level (p < 0.05), CVC ratio (p < 0.001), all-cause mortality (p < 0.001) and cardiac mortality (p < 0.001) were all higher than those in the low TN-C group, while blood flow rate (p < 0.05) was lower (Table 4). Kaplan–Meier survival curve revealed higher all-cause and cardiac mortality rates in the high TN-C group (Fig. 2a and b) (Log rank p = 0.000 and p = 0.001, respectively).